Coronary Disease/Myocardial Infarction
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Discrimination, Disparities, and Dangerous Cardiovascular Outcomes
A pair of papers underscore the persistent inequities that negatively affect the health of people of color, especially African Americans.
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Two Possible Mechanisms of Disease in COVID-19
COVID-19 infection may be associated with an increased risk of blood clotting and related thrombotic events, but there are insufficient data to support indiscriminately discontinuing medications that play a critical role in the management of chronic cardiovascular disease.
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Is Exercise ECG Testing Dead?
A post-hoc analysis of the SCOT-HEART trial demonstrated exercise ECG is predictive of future coronary heart disease events and mortality. However, coronary CT angiography is more accurate for the detection of coronary artery disease and is more strongly associated with future coronary events.
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Clinical vs. Genetic Risk for Coronary Disease
A study of the utility of a polygenetic score for coronary artery disease risk was compared to the pooled cohort equation (PCE) for determining which primary prevention patients would benefit from statin use. Only at the top 5% risk stratum did the genetic score exceed an odds ratio for coronary disease of 2. Using these data would increase statin recommendations by 4% vs. the PCE.
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Coronary Calcium to Guide Aspirin Primary Prevention
Researchers analyzed the MESA study to determine the comparative value of the pooled risk equation vs. CT coronary artery calcium score for determining which aspirin-naïve patients < age 70 years without overt coronary artery disease would benefit most from primary prevention with aspirin. They found a calcium score of > 100 was superior for this determination.
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Coronary CT Angiography to Identify Plaque Stabilization
Researchers identified subjects with no known coronary artery disease drawn from a large international, multicenter registry of coronary CT angiography. The authors demonstrated those with a high density of calcium plaques experienced the fewest events, suggesting high-density calcium plaques are stable.
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Investigators Uncover More Troubling Data About the Adverse Health Effects of Sugar-Sweetened Beverages
Recent study revealed women who consume just one such beverage per day were at a much higher risk for stroke and cardiovascular disease.
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Appropriate Cardiac Testing in an Inappropriate World, Part 2: Cardiac Tests
This article addresses specifics of the cardiac testing options, considering their appropriate indications, choices of approach, risks, and costs.
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Predicting the Response to CRT-D Therapy
This paper gives the results of a substudy from the Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy (MADIT-CRT) trial. -
Indication for ICDs in Arrhythmogenic RV Cardiomyopathy Patients
Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is an uncommon condition with a wide spectrum of possible clinical presentations. Implantable defibrillators (ICDs) are standard therapy for treating ARVD/C patients who present with sustained ventricular tachycardia (VT) or cardiac arrest.