Triglyceride-Lowering Therapy and Cardiovascular Events
Researchers studied pemafibrate vs. placebo in patients with type 2 diabetes, mild-to-moderate triglyceride elevations, and low levels of HDL and well-controlled LDL cholesterol. Despite a 31% reduction in triglyceride levels, there was no improvement in the risk of cardiovascular outcomes over a median follow-up of 3.4 years.
Long-Term Statin Use Associated with Lower Stroke Risk
A cohort of Danish patients who were taking the cholesterol control medication were less likely to experience an intracerebral hemorrhage.
Statins Plus Ezetimibe vs. Statins Alone
A comparison of rosuvastatin 10 mg/day plus ezetimibe (10 mg/day) to 20 mg/day of rosuvastatin alone showed non-inferiority in three-year major cardiovascular outcomes, with lower LDL cholesterol levels and fewer episodes of drug discontinuation or dose reductions in the combination therapy group.
Understanding Statin-Related Muscle Pain and Cardiovascular Benefits
A review of large-scale, randomized, double-blind trials of statin therapy suggested statins are responsible for only a small excess of muscle pain symptoms in patients taking these drugs.
Secondary Prevention Statin Adherence and Major Adverse Cardiovascular Events
A study of adherence to statin therapy after an atherosclerotic cardiovascular event demonstrated full adherence for five years was associated with significantly lower major adverse cardiovascular events, although only 5% of these patients achieved full compliance for five years.
Men More Likely to Produce High-Risk, Dangerous Carotid Artery Plaques
Investigators found significant differences in mean total plaque volume between men and women. Men were more likely to experience intraplaque hemorrhage and produce lipid-rich necrotic cores with coexistence of calcifications. Men also were more likely to exhibit thin or ruptured fibrous caps or ulcerations in their atherosclerotic plaques.
USPSTF Weighs in on Key Cardiology Topics
Should clinicians screen asymptomatic older patients for atrial fibrillation? What is the best treatment course for patients without cardiovascular disease risk?
Inclisiran Injection (Leqvio)
Inclisiran can be prescribed as an adjunct to diet and maximally tolerated statin therapy for adults with heterozygous familial hypercholesterolemia or clinical atherosclerotic cardiovascular disease who required additional low-density lipoprotein cholesterol lowering.
Heart Health and Cognitive Decline: Who Fares Better?
More middle-age men might be living with various cardiovascular risk factors and diseases, but the associated negative effects on cognition could be worse for women of the same age with the same conditions.
Progression of Coronary Calcium on Statin Treatment
In those treated with statins vs. those who were not, statins decreased plaque volume in plaques with little or no calcium (plaque regression) and increased calcium density without changes in plaque volume in calcified plaques (plaque stabilization).