Controlling Blood Pressure During Pregnancy Could Lower Dementia Risk
Investigators found an association between high blood pressure during pregnancy and a higher likelihood of developing dementia later in life.
Electrodiagnostic Features of Vasculitic Neuropathy
Electrophysiological studies of vasculitic neuropathy indicate that the best discriminators of vasculitis vs. other axonal neuropathies are the side-to-side differences between the same bilateral nerves. When the diagnosis is uncertain, nerve biopsy may be definitive.
Insulin Resistance at the Blood-Brain Barrier in Alzheimer’s Disease
Alterations in cerebrovascular insulin receptor isoform levels are associated with Alzheimer’s disease pathology and cause deficits in insulin signaling at the level of the blood-brain barrier.
Leriglitazone for the Treatment of Adrenomyeloneuropathy
A 96-week trial of leriglitazone to slow the progression of symptoms in adrenomyeloneuropathy did not meet the primary endpoint. However, post-hoc analyses revealed a beneficial effect in patients treated earlier in their disease course.
Self-Treatment of Recurrent Benign Paroxysmal Positional Vertigo
Using a cell phone-based app, self-treatment of recurrent benign positional paroxysmal vertigo was feasible and effective in most patients.
A Population-Based Study of Progressive Multifocal Leukoencephalopathy
In this population-based cohort study of 584 cases of progressive multifocal leukoencephalopathy (PML), predisposing conditions with the highest risk of PML were human immunodeficiency virus (HIV) infection, hematological malignancies, chronic inflammatory disease, solid organ transplantation, solid malignancies, and primary immune deficiency. The one-year mortality rate was 38.2% for all cases of PML. Factors independently associated with higher mortality rate were older age, male gender, and immunosuppressive diseases, such as hematological malignancies, solid neoplasms, and HIV.
Long-Term Air Pollution Exposure Could Raise Risk for Depression, Anxiety
Two research groups reported on breathing dirty air and how that affects mental health.
Cumulative Estrogen Exposure Linked to Lower Stroke Risk
These findings could help clinicians sustain their postmenopausal patients’ neurological health.
Efficacy and Safety of Leriglitazone in Patients with Friedreich Ataxia
Friedreich ataxia (FRDA) is an autosomal, recessive, multisystemic disease characterized by progressive weakness, ataxia, and dysarthria starting in childhood and resulting in severe morbidity and premature death. There are no approved treatments for FRDA. With recent preclinical studies suggesting potential benefit of PPARPγ agonists in motor function and reduced radiographic disease activity, the current study explores the effect of leriglitazone, a PPARPγ agonist, in patients with moderate to severe FRDA.
Late-Onset Pompe Disease: A Review of Clinical Features
In this systematic literature review of studies that evaluate motor and locomotion function in patients with adult, late-onset Pompe disease, the clinical spectrum reveals weakness of respiratory, axial, and proximal limb muscles.