OB/GYN Clinical Alert
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Cabergoline: An Effective Intervention for Unwanted Lactation After Second Trimester Uterine Evacuation
In this double-blind, randomized controlled trial among 73 patients between 18 and 28 weeks’ gestation undergoing dilation and evacuation or induction of labor for abortion or fetal demise, a one-time dose of 1 mg of cabergoline compared to placebo reduced post-delivery lactation-related breast symptoms in the treatment arm (27.8% vs. 97.0%; relative risk, 0.05; 95% confidence interval, 0.01-0.33).
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Effectiveness and Safety of Low-Dose Aspirin to Prevent Preterm Preeclampsia
An aspirin dosage of 150 mg to 162 mg per day, when started in the first trimester of pregnancy, was linked to a decreased risk of preterm preeclampsia compared to an aspirin dosage of 75 mg to 81 mg per day.
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Is It Safe to Skip the Pelvic Examination Before Gender-Affirming Hysterectomy and Vaginectomy?
A retrospective chart review of individuals undergoing gender-affirming hysterectomy, vaginectomy, or both found no difference in 30-day perioperative outcomes between those who received a preoperative internal pelvic examination and those who did not. These findings indicate that omitting such potentially triggering exams may be safe.
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Preconception Hepatitis B and Congenital Heart Disease
A new study suggests that both women and men who have had hepatitis B infection prior to conceiving offspring are more likely to give birth to children with congenital heart disease.
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Maternal, Fetal, and Infant Implications of a Positive Syphilis Screening During Pregnancy
Although syphilis screening during pregnancy is effective in identifying maternal syphilis, it is not without consequences. False-positive syphilis testing can result in unwarranted antibiotic therapy; re-screening based on risk is not always consistent, and among pregnant women who truly test positive to syphilis, treatment is not always optimized to prevent congenital syphilis.
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Barriers to Urogynecologic Care
There is a paucity of literature on barriers to urogynecologic care in racial/ethnic minorities. Continued evaluation is needed to better understand the unique barriers to urogynecologic care in these populations.
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Ovarian Torsion: What Is the Best Surgical Management Strategy?
In this national retrospective cohort study from 2008 to 2020, there were 1,791 surgeries for adnexal torsion, with 30.3% involving ovarian conservation and the remainder undergoing oophorectomy. The proportion of oophorectomies compared to ovarian conservation decreased slightly over the study period (average decrease, -1.6% per year; 95% confidence interval, -3.0%- to -0.22%).
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Oral Medication to Treat ‘Hot Flashes’ Could Be Available Soon
The FDA has approved the first neurokinin 3 receptor antagonist to alleviate symptoms associated with moderate to severe vasomotor symptoms caused by menopause.
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Identifying and Testing BRCA Gene Variant Carriers Meeting NCCN Criteria
A large percentage of patients who meet criteria for breast cancer gene (BRCA) testing based on family history do not have it completed until after a personal cancer diagnosis, thus missing the opportunity for risk-reducing strategies.
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Surgical Management of Missed and Incomplete Abortion: Is Hysteroscopy Useful?
In this randomized controlled trial of 563 women comparing vacuum aspiration and operative hysteroscopy for incomplete spontaneous abortion, there was no difference in pregnancy rates within the following two years (62.8% hysteroscopy vs. 67.6% vacuum aspiration; risk difference, -4.8%; 95% confidence interval, -13% to 3%).