OB/GYN Clinical Alert
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Is Vaginal Carbon Dioxide Laser an Effective Treatment for the Genitourinary Syndrome of Menopause?
In this double-blinded, randomized controlled trial, fractional carbon dioxide vaginal laser was no better than sham laser in improving Female Sexual Function Index scores among 72 breast cancer survivors on aromatase inhibitors over a six-month period.
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Controlling Blood Pressure During Pregnancy Could Lower Dementia Risk
Investigators found an association between high blood pressure during pregnancy and a higher likelihood of developing dementia later in life.
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Breast Milk Feeding Among Women Who Had Been Infected with SARS-CoV-2 During Their Pregnancy
Both breast milk feeding during the postpartum hospital stay and infant rooming-in during this time were common in the five states studied from March 29 to Dec. 31, 2020, among the births that occurred to women who had a laboratory-confirmed case of SARS-CoV-2 during their pregnancy.
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Identifying High-Risk Cancer Patients Through Appropriate Screening
Less than 20% of average-risk women receive guideline-adherent cervical cancer screening, and guideline-adherent screening was highest for primary human papillomavirus testing.
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Second Trimester Induction of Labor: Do Multiple Prior Cesarean Deliveries Increase the Risk of Complications?
In this retrospective cohort study among patients who underwent second trimester induction of labor for fetal demise or pregnancy termination, those with two or more prior cesarean deliveries had an increased risk of uterine rupture (6.25%) compared to those with one prior cesarean delivery (0%) or no prior cesarean delivery (0%) (P = 0.004).
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Vaginal Cleansing at the Time of Cesarean Delivery to Prevent Puerperal Infection
Povidone-iodine (Betadine) vaginal cleansing prior to an unplanned cesarean delivery for labor-related indications did not lessen the postoperative infectious morbidity, and, therefore, its regular use in women having a cesarean delivery for labor-related indications is not supported.
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Cumulative Estrogen Exposure Linked to Lower Stroke Risk
These findings could help clinicians sustain their postmenopausal patients’ neurological health.
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Probiotics and Iron Intake in Pregnancy
In a randomized controlled trial, a significantly smaller decrease in serum ferritin was observed in pregnant women with the intake of a Lactiplantibacillus plantarum 299v supplement containing a low dose of iron, folic acid, and ascorbic acid than in the placebo group.
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Provider Perceptions of Neonatal Survival for Fetuses Born at 22 Weeks of Gestation
Prognostic differences exist among neonatal and obstetric care providers when neonates are delivered at 22 weeks of gestation. However, there are no statistically significant differences in the gestational age at which providers recommend active treatment or antenatal corticosteroids.
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New Treatments for Uterine Fibroids
In this prospective, open-label, single-arm trial of 149 individuals with heavy menstrual bleeding and uterine leiomyomas, daily relugolix combination therapy (relugolix 40 mg, estradiol 1 mg, and norethindrone acetate 0.5 mg) resulted in a mean menstrual blood loss reduction of 90%, and 70% of the participants achieved amenorrhea by the end of the 52-week period. Similar results were found for other arms of the trial among women who crossed over from placebo and relugolix-only therapy to relugolix combination therapy.