Parkinson Disease
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Focused Ultrasound Ablation of the Subthalamic Nucleus for Parkinson’s Disease Tremor
Researchers demonstrated the long-term efficacy and safety of unilateral MRI-guided high-frequency ultrasound subthalamotomy for Parkinson’s disease patients with motor fluctuations and dyskinesia three years after the procedure.
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Updated Tactics for Parkinson’s Disease Study Recruitment
Remote, decentralized studies allow for the recruitment of large, geographically dispersed cohorts from a single location. In considering whether to use a decentralized design or to include remote assessments, the research team must determine if these methods can adequately answer the question under study.
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Does Amantadine Treatment Reduce Levodopa-Induced Dyskinesias?
Early treatment with amantadine may delay levodopa-induced dyskinesia onset more than treatment with other symptomatic agents.
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Many Parkinson’s Research Participants Cannot Recall Study Risks
Rather than consenting an individual in the office during the presurgical visit, at a time when the patient was already receiving a large amount of information, the outreach could be conducted by phone later. This would give the subject time to carefully review the study materials.
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Is Physical Activity Associated with Mortality Risk in Parkinson’s Disease?
In individuals with Parkinson’s disease (PD), physical activity (PA) at all intensities was associated with lower all-cause mortality rates, with the greatest reduction seen in individuals who maintained PA before and after PD diagnosis.
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Association of Sleepwalking and REM Sleep Behavior Disorder in Men with Parkinson’s
In this retrospective, cross-sectional study of men, both sleepwalking and rapid eye movement sleep behavior disorder were associated with the development of Parkinson’s disease. -
Cognitive Benefit of Rivastigmine in Parkinson’s Disease Dementia with Orthostatic Hypotension
Individuals with Parkinson’s disease dementia and orthostatic hypotension (OH) showed more robust cognitive improvement from rivastigmine vs. those without OH. The anti-OH effect of rivastigmine probably mediates this better response.
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Vitamins C and E Antioxidants Linked to Lower Parkinson’s Risk
These brain-boosting nutrients are packed into certain fruits and vegetables.
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Submentalis REM Sleep Muscle Activity: A Potential Biomarker for Synucleinopathy
Objective findings during polysomnography (REM sleep without atonia), as diagnosed with submentalis EMG recordings, may be a biomarker for synucleinopathies, such as Parkinson’s disease and multiple system atrophy.
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REM Behavior Disorder, Dementia, and Parkinson’s Disease
In this well-designed prospective cohort study of patients with REM behavior disorder, the investigators reported that 73.5% of patients developed a neurodegenerative disorder after a 12-year follow-up.