Pulmonary/Critical Care
RSSArticles
-
Withholding Intubation in Select Comatose Patients with Acute Poisoning May Be Beneficial
In this unblinded, randomized trial of adults presenting with acute poisoning and a Glasgow Coma Scale score less than 9, those for whom intubation was withheld unless emergently indicated had decreased intensive care unit and hospital lengths of stay and a lower rate of pneumonia.
-
Low-Dose vs. Conventional-Dose TMP-SMX to Treat Pneumocystis Pneumonia in Non-HIV Patients
In patients without human immunodeficiency virus who were diagnosed with Pneumocystis jirovecii pneumonia, mortality rates were similar between the low-dose vs. conventional-dose trimethoprim-sulfamethoxazole (TMP-SMX) groups, while low-dose TMP-SMX was associated with fewer adverse events.
-
High-Flow Nasal Oxygen for Acute Hypoxemic Respiratory Failure Due to COVID-19 Is Safe Initiated Outside the ICU
This study of hospitalized adults with COVID-19-related hypoxemic respiratory failure found that initiation of high-flow nasal oxygen on the wards was safe, resulted in comparable intubation and mortality rates, and led to less time in the intensive care unit.
-
Norepinephrine Can Be Infused Safely Via Peripheral IV Catheter
Peripheral administration of norepinephrine has a low risk of extravasation if following an operationalized protocol.
-
ICU Delirium Linked to Post-Discharge Change in Cancer Treatment and Higher Mortality Among Cancer Patients
In this single-center, retrospective cohort study, intensive care unit (ICU) delirium was associated with a higher rate of cancer treatment modification, only partly due to worsening performance status, after discharge and higher one-year mortality.
-
Does Alkaline Phosphatase Reduce Sepsis-Associated Acute Kidney Injury?
This Phase III, international, multicenter, double-blind, randomized controlled trial did not show a reduction in 28-day all-cause mortality with ilofotase alfa (recombinant human alkaline phosphatase). However, the study showed evidence to suggest that ilofotase alfa reduced major adverse kidney events at 90 days, mainly driven by lowering the incidence of renal replacement therapy through day 90 in these patients.
-
Ventilation and Oxygenation Considerations During and After Cardiopulmonary Resuscitation
With a multitude of recommendations spanning from monitoring during cardiopulmonary resuscitation (CPR) to post-arrest targeted temperature management, the specific focus of this article is to review considerations related to ventilation and oxygenation during and after CPR.
-
Percutaneous Coronary Intervention vs. Placebo for Stable Angina Patients
In this randomized trial of patients with stable angina and objective evidence of ischemia, percutaneous coronary intervention resulted in a significant reduction in angina compared to a placebo procedure.
-
Small-Volume Blood Collection May Reduce Transfusion Needs in the ICU
The STRATUS randomized clinical trial was a stepped-wedge cluster randomized trial in 25 adult medical-surgical intensive care units (ICUs) in Canada that studied standard-volume to small-volume vacuum tubes for blood collection in the ICU. In the primary analysis, there was no significant difference in red blood cell transfusion between groups. However, in a pre-specified secondary analysis, red blood cell transfusion decreased after the transition from standard-volume tubes to small-volume tubes.
-
Buprenorphine May Be an Effective Alternative to Full Opioids for Pain in the ICU
In a small, single-center, retrospective, propensity-matched cohort study examining enteral oxycodone vs. sublingual buprenorphine in a critically ill population, pain control was equivalent, indicating that sublingual buprenorphine may be an effective and appropriate alternative.