Bacterial Infections
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A Rapid Molecular Test Improves Time to Appropriate Therapy and Mortality in Patients with CRE Bacteremia
A multicenter observational study of patients with carbapenem-resistant Enterobacterales bacteremia found that time to receipt of active antibiotic therapy and mortality were improved in those whose blood cultures underwent rapid molecular testing for the Klebsiella pneumoniae carbapenemase gene. The mortality rate was 10% with ceftazidime-avibactam compared to 31% with polymyxin monotherapy.
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Nationwide Outbreak of Extensively Drug-Resistant Pseudomonas aeruginosa Infections from Contaminated Eye Drops
An outbreak of extensively drug-resistant Pseudomonas aeruginosa infection has been traced to use of contaminated artificial tears.
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Comparison of Postoperative Antibiotic Regimens for Complex Appendicitis: Is Two Days as Good as Five Days?
In a pragmatic, open-label, randomized trial conducted at 15 hospitals in the Netherlands, two days of postoperative intravenous antibiotics for complex appendicitis was found to be noninferior to five days in terms of infectious complications and mortality within 90 days.
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Infectious Disease Alert Updates
California Firefighters at Risk for Cocci; Hyperglycemia and Diabetes with INSTIs; Positive Sputum in Extra-Pulmonary Tuberculosis
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A Comparison of Ceftaroline and Daptomycin in Treatment of MRSA Bloodstream Infections
Ceftaroline is an acceptable alternative therapy for treatment of methicillin-resistant Staphylococcus aureus bacteremia.
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Infectious Disease Alert Updates
Is Your Hospital Room Toxigenic?; Reduction of HOCDI — Gaming the System?
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Fecal Microbiota, live-jslm (Rebyota)
Rebyota can be prescribed to prevent recurring Clostridioides difficile infection for patients age 18 years and older who are following antibiotic treatment for recurring episodes.
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When More Is Not Better: Treatment of Prosthetic Valve Endocarditis Due to Staphylococci
Clear evidence of benefit from adjunctive administration a β-lactam and/or a glycopeptide in the treatment of prosthetic valve endocarditis due to staphylococci is lacking. Current guidelines need to be reassessed.
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It’s Not All About the Cough
Be careful about relying on clinical queries that focus on the presence of cough for two or more weeks, which could lead to delays in the diagnosis of nearly half of pulmonary tuberculosis cases.
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WHO Lobbies for Updated Tuberculosis Vaccines
International organization says these investments could drive economic growth, improve health equity and antimicrobial stewardship, and lower mortality rates.