Head Trauma
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EEG-based Metrics After Severe Brain Injury
In this cohort study of 104 patients with disorders of consciousness, the authors demonstrated a strong correlation between EEG-based metrics and clinical diagnosis using quantitative behavioral scales, brain metabolism as measured by PET, and clinical outcomes at one year.
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Mild Traumatic Brain Injury Induces Altered Sleep and Impaired Memory
Traumatic brain injury may induce a chronic state of altered sleep with impaired memory consolidation and mood disorders.
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Serum and CSF Biomarkers of Brain Injury After Sports-related Concussion
ABSTRACT & COMMENTARY: So far none of the currently measured biomarkers has sufficient sensitivity or specificity to be clinically useful.
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Linking Traumatic Brain Injury and Parkinson’s Disease: The Evidence Builds
A retrospective study based on an administrative database compared more than 50,000 admissions with traumatic brain injury (TBI) with more than 100,000 admissions for other traumatic injury, and found that TBI in individuals older than 55 years of age led to a 44% increased risk of developing Parkinson’s disease in the ensuing 5-7 years.
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Does Traumatic Brain Injury Cause Sleep Disruption?
In a well-designed animal model of traumatic brain injury, a sleep disorder was induced that resembles, in many ways, what is observed in spontaneous human narcolepsy.
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Take Me Out of the Ball Game: Acute Management and Long-term Consequences of Concussion in Childhood
The developing brain of a child may be particularly susceptible to injury from mild traumatic brain injury, such as a concussion. Recommending a longer period of strict rest after a concussion does not provide additional benefit when compared to consensus guidelines for care after a concussion in children and adolescents. However, in retired former NFL players, exposure to tackle football prior to age 12 is associated with executive dysfunction, memory impairment, and lower estimated verbal IQ later in life. -
Pharmacology Watch
New recommendations for HPV vaccine; guidelines for treatment of essential tremor; updates on smoking cessation drugs; and FDA actions. -
Rituximab May Be Effective for Refractory Myasthenia Gravis
In a restrospective review, rituximab appeared beneficial for patients with medication-resistant myasthenia gravis. -
When Is it Best to Evaluate the Results of a CSF Tap Test?
The tap test has variable results as a tool to assess patients with a presumed diagnosis of normal pressure hydrocephalus. -
Surgical Treatment of Brain Metastases
Surgical removal of brain metastases remains an important part of palliative therapy for metastatic cancer.