Infectious Disease
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Induction Therapy for HIV/AIDS-Related Disseminated Histoplasmosis with Single High-Dose Liposomal Amphotericin B
In a Phase II randomized clinical trial involving 118 participants in Brazil with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS)-related disseminated histoplasmosis, induction therapy with single high-dose (10 mg/kg) liposomal amphotericin B was safe and non-inferior as compared with standard dose (3 mg/kg) liposomal amphotericin B given once daily for 14 days.
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Infectious Disease Alert Updates
Head and Neck Cancer Worse in HIV; Syphilis RPR May Fluctuate Before Treatment
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Biden Announces Choice for New CDC Director
Mandy Cohen will succeed Rochelle Walensky, who will step down at the end of June.
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The Current State of RSV
Respiratory syncytial virus is a common virus encountered in the ED, with myriad presentations and complications that clinicians must be able to identify and manage. The authors provide state-of-the-art diagnostic and management strategies for the acute care clinician.
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Scientists Use Artificial Intelligence While Searching for ‘Superbug’ Solutions
Researchers enlisted the help of technology to find an antibiotic that could fight multidrug-resistant bacteria.
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Respiratory Syncytial Virus Vaccine, Adjuvanted (Arexvy)
Arexvy can be administered to prevent lower respiratory tract disease caused by respiratory syncytial virus in patients age 60 years and older.
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Inappropriate Antibiotic Prescribing Is Common for Elective Surgeries
A retrospective cohort study of adults who underwent an elective craniotomy, hip replacement, knee replacement, spinal procedure, or hernia repair revealed only 59% adhered to recommended guidelines on prophylactic antibiotic prescribing. Unnecessary vancomycin use was the most common reason for nonadherence and had 19 times higher risk for acute kidney injury.
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Blastomycosis Outbreak
The largest reported outbreak of blastomycosis has affected at least 115 employees, contractors, or visitors to a paper mill in the Michigan Upper Peninsula.
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Infectious Disease Alert Updates
Immunocompromised Patients with Persistent COVID-19; Endemic Mycoses Are No Longer ‘-Demic’
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Preparing for Fresh Concerns of Poliovirus and Acute Flaccid Myelitis
What will be the next health crisis? Could it be wild-type poliovirus, vaccine-derived poliovirus, or the similar condition of acute flaccid myelitis? Are you prepared to recognize and anticipate the complications? The authors prepare clinicians for the acute management of each of these conditions.