Articles Tagged With: antibiotics
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Clinicians Prescribe Antibiotics for Excessive Duration in Patients With a Diagnosis of Acute Sinusitis
Clinicians inappropriately prescribe antibiotics most often to patients with a diagnosis of acute sinusitis for durations much longer than recommended.
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Why IDSA Did Not Support the Surviving Sepsis Campaign
The Infectious Diseases Society of America withheld its support for the Surviving Sepsis guidelines. The general concerns included vagueness and inconsistency in definition of sepsis, “one size fits all” prescription of time to administer antibiotics, lack of clarity around drawing blood cultures through IV catheters, recommendation of combination antibiotics, lack of definition around when to use procalcitonin levels, when and how to use pharmacokinetic and pharmacodynamic data effectively, prolonged antibiotic “prophylaxis,” and duration of therapy.
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Oral Antibiotics May Increase the Risk for Nephrolithiasis
A case-control study found that receipt of an oral antibiotic in the preceding three to 12 months was associated with nephrolithiasis. The risk persisted up to five years, and younger patients were at increased risk.
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Antibiotic Use in Infancy Associated With Allergic Disease During Childhood
In a large population-based study, antibiotic use during the first six months of life was associated with a two-fold increase in asthma and a 1.5-fold increase in allergic disease during early childhood.
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Antibiotic Cycling Is Not Useful for Reducing Antibiotic-resistant Gram-negative Pathogens in Patients Admitted to Intensive Care Units
A randomized study that included eight intensive care units in Europe found no reduction in mortality or carriage of antibiotic-resistant gram-negative pathogens with antibiotic cycling compared to antibiotic mixing.
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What Effect Do Antibiotics Have on Hormonal Contraception?
Data do not support drug interactions between hormonal contraceptives and non-rifamycin antibiotics.
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Prolonged vs. Short Duration Infusion of Beta-lactam Antibiotics: The Verdict Is In
When compared to shorter infusion duration, prolonged infusion of anti-pseudomonal β-lactam antibiotics was associated with reduced mortality.
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Which Antibiotics Are Safe in the First Trimester of Pregnancy?
A total of 7.2% of pregnant women were diagnosed with a urinary tract infection, and of these, 69% filled an antibiotic prescription. The most common antibiotics prescribed in the first trimester were nitrofurantoin, ciprofloxacin, cephalexin, and trimethoprim-sulfamethoxazole.
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Stewardship, Science, and Spirituality
Awareness of a patient’s and family’s belief system might help physicians appropriately frame explanations about the importance of antimicrobial stewardship.
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Antibiotics and Adverse Events: Doctors, Do No Harm
A retrospective study found that among 1,488 hospitalized patients who received an antibiotic, 298 (20%) experienced at least one antibiotic-associated adverse drug event. Furthermore, 287 (19%) of the antibiotic regimens were not clinically indicated, and 56 (20%) of these were associated with an adverse drug event.